Completed Clinical Trials
Completed mesothelioma clinical trials represent the culmination of extensive research, providing valuable insights into the disease and potential treatments. These trials entail comprehensive assessments, and their outcomes hold significant importance for both medical professionals and individuals affected by mesothelioma.
Why are Completed Clinical Trials Important?
Clinical trials serve as crucial tools in unraveling the complexities of mesothelioma, shedding light on its development and therapeutic approaches. These trials are classified as “completed” when all treatments and follow-up procedures are concluded. This signifies the collection of vital data from the last patient under treatment. At this juncture, researchers delve into the study’s results to address pivotal questions:
- Treatment Effectiveness: The primary inquiry revolves around whether the treatment demonstrated efficacy in managing mesothelioma.
- Balancing Benefits and Risks: Researchers evaluate whether the benefits of the treatment outweigh any associated risks.
- Further Study Necessity: The analysis determines whether the treatment warrants additional investigation to refine its effectiveness.
- FDA Approval Consideration: Researchers assess whether the treatment meets the criteria for approval by the U.S. Food and Drug Administration (FDA).
Upon the completion of the analysis phase by study coordinators, the findings may be disseminated in medical journals or shared on the ClinicalTrials.gov record to ensure broader accessibility.
Clinical Trial Results Advance Mesothelioma Knowledge
Numerous completed clinical trials have yielded promising results, offering hope for improved outcomes in mesothelioma treatment. Below are notable examples of such trials:
- Immunotherapy for Inoperable Pleural Mesothelioma (CheckMate-743): This trial investigated an immunotherapy combination treatment in comparison to standard chemotherapy, resulting in a significant increase in median survival. Patients treated with Opdivo® and Yervoy® exhibited a median survival of 18.1 months, as opposed to 14.1 months with standard chemotherapy. The FDA approved this regimen in October 2020.
- A New Treatment for Inoperable Pleural Mesothelioma (STELLAR): This study explored an innovative, electric field-based approach, demonstrating encouraging survival rates with minimal systemic toxicity. The median overall survival reached 18.2 months, offering hope for inoperable pleural mesothelioma patients. The Novo-TTF-100L System gained FDA approval in 2019, providing a new avenue of treatment.
- Improved Survival in Select Patients With Unresectable Pleural Mesothelioma (MAPS): This trial assessed the impact of an immunotherapy drug, Avastin®, in conjunction with standard chemotherapy. The results indicated improved survival, with patients receiving chemotherapy and Avastin® experiencing a median survival of 18.8 months, compared to 16.1 months with chemotherapy alone.
These insights from completed clinical trials not only deepen our understanding of mesothelioma but also offer tangible advancements in treatment options. It is essential to note that while some treatments have gained FDA approval, others may still hold promise and could be considered for patients who can tolerate them.
Mesothelioma clinical trials play a pivotal role in shaping our comprehension of the disease and improving treatment options. The findings from these trials instill hope and optimism for both patients and medical professionals.
COMPLETED MESOTHELIOMA CLINICAL TRIALS
- First-in-Human Study of S-588210 (S-488210+S-488211)
- Conditions: Mesothelioma
- Last Updated: January 25, 2022
- Status: Completed
- Intravenous Magnesium for Cisplatin Patients
- Conditions: Mesothelioma
- Last Updated: January 10, 2022
- Status: Completed
- Location: Boston, MA.
- Mesothelin-Targeted Immunotoxin LMB-100 for Malignant Mesothelioma
- Conditions: Mesothelioma
- Last Updated: December 29, 2021
- Status: Completed
- Location: Bethesda, MD.
- Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies
- Conditions: Carcinoma, Lung Neoplasms, Melanoma, Stomach Neoplasms, Breast Neoplasms, Mesothelioma, Squamous Cell Carcinoma of Head and Neck
- Last Updated: November 12, 2021
- Status: Completed
- Locations: Los Angeles, CA. Jackson, MS. Hackensack, NJ. Huntsville, NC.
- Nintedanib for Recurrent Malignant Pleural Mesothelioma
- Conditions: Mesothelioma
- Last Updated: November 10, 2021
- Status: Completed
- Locations: Ann Arbor, MI. Detroit, MI. New York, NY.
- Vinorelbine in Mesothelioma
- Conditions: Mesothelioma
- Last Updated: October 4, 2021
- Status: Completed
- Intracavitary Cisplatin-Fibrin Localized Chemotherapy After P/D or EPP for Malignant Pleural Mesothelioma
- Conditions: Mesothelioma
- Last Updated: September 28, 2021
- Status: Completed
- BBI608 in Combination With Pemetrexed and Cisplatin for Malignant Pleural Mesothelioma
- Conditions: Mesothelioma
- Last Updated: September 5, 2021
- Status: Completed
- Locations: Various cities across the United States.
- Pemetrexed Disodium/Observation for Malignant Pleural Mesothelioma
- Conditions: Mesothelioma
- Last Updated: August 16, 2021
- Status: Completed
- Locations: Multiple cities across the United States.
- Early Palliative Care for Incurable Lung and Gastrointestinal Cancer
- Conditions: Lung Neoplasms, Small Cell Lung Carcinoma, Mesothelioma, Bile Duct Neoplasms, Anxiety Disorders
- Last Updated: July 22, 2021
- Status: Completed
- Locations: Various cities across the United States.
- Lurbinectedin Monotherapy for Progressive Malignant Pleural Mesothelioma
- Conditions: Mesothelioma
- Last Updated: July 13, 2021
- Status: Completed
- CBP501 + Pemetrexed + Cisplatin for MPM (Phase I/II)
- Conditions: Mesothelioma
- Last Updated: June 30, 2021
- Status: Completed
- Locations: Various cities across the United States.
- Alvopem® (Pemetrexed) Safety Assessment
- Conditions: Lung Neoplasms, Carcinoma, Mesothelioma
- Last Updated: April 10, 2021
- Status: Completed
- Safety and Efficacy of LAG525 Single Agent and in Combination With PDR001
- Conditions: Various Malignancies
- Last Updated: April 6, 2021
- Status: Completed
- Locations: Various international locations.
- Olaparib in People With Malignant Mesothelioma
- Conditions: Mesothelioma
- Last Updated: March 16, 2021
- Status: Completed
- Location: Bethesda, MD.
- Study of the EZH2 Inhibitor Tazemetostat in Malignant Mesothelioma
- Conditions: Mesothelioma
- Last Updated: March 16, 2021
- Status: Completed
- Locations: Various cities across the United States.
- Diadem Investigating Durvalumab Activity and Safety
- Conditions: Mesothelioma
- Last Updated: March 3, 2021
- Status: Completed
- Nivolumab Monotherapy or Nivolumab Plus Ipilimumab for Unresectable Malignant Pleural Mesothelioma
- Conditions: Mesothelioma
- Last Updated: February 9, 2021
- Status: Completed
- Gemcitabine and Imatinib Mesylate Combination for Pleural Mesothelioma
- Conditions: Mesothelioma
- Last Updated: January 20, 2021
- Status: Completed
- Location: Rozzano, Michigan.
- Tivantinib Plus Pemetrexed and Carboplatin Combination Study
- Conditions: Mesothelioma, Lung Neoplasms
- Last Updated: January 20, 2021
- Status: Completed
- Ipilimumab and Nivolumab Treatment for Malignant Pleural Mesothelioma
- Conditions: Mesothelioma
- Last Updated: January 19, 2021
- Status: Completed
- Intrapleural Measles Virus Therapy for Malignant Pleural Mesothelioma
- Conditions: Mesothelioma, Lung Neoplasms
- Last Updated: January 8, 2021
- Status: Completed
- Location: Rochester, MN.
- Cytoreductive Surgery and Hyperthermic Intraperitoneal Mitomycin-C
- Conditions: Mesothelioma, Peritoneal Neoplasms, Pseudomyxoma Peritonei, Appendiceal Neoplasms, Gastric Carcinoma
- Last Updated: January 7, 2021
- Status: Completed
- Location: Bronx, NY.
- Pharmacokinetic, Safety, and Efficacy of Oral LBH589
- Conditions: Mesothelioma, Non-Small Cell Lung Carcinoma
- Last Updated: December 16, 2020
- Status: Completed
- Locations: Fayetteville, AR. Augusta, GA. Chicago, IL. Houston, TX.
- Intrapleural AdV-tk Therapy for Malignant Pleural Effusion
- Conditions: Mesothelioma, Malignant Pleural Effusion
- Last Updated: December 2, 2020
- Status: Completed
- Location: Philadelphia, PA.
- Safety and Tolerability Study of INCAGN02385 in Select Advanced Malignancies
- Conditions: Various Malignancies
- Last Updated: October 28, 2020
- Status: Completed
- Locations: Los Angeles, CA. Hackensack, NJ. Huntersville, NC. Nashville, TN.
- Phase II Anetumab Ravtansine as 2nd Line Treatment for Malignant Pleural Mesothelioma (MPM)
- Conditions: Mesothelioma
- Last Updated: October 28, 2020
- Status: Completed
- Locations: La Jolla, CA. Aurora, CO. Norwich, CT. Tampa, FL. Chicago, IL. New Orleans, LA. Bethesda, MD. Rochester, MN. Buffalo, NY. New York, NY. Durham, NC. Cleveland, OH. Dallas, TX. Houston, TX.
- Suberoylanilide Hydroxamic Acid (Vorinostat, MK-0683) Study
- Conditions: Mesothelioma
- Last Updated: October 1, 2020
- Status: Completed
- Cisplatin, Pemetrexed and Bevacizumab for Untreated Malignant Mesothelioma
- Conditions: Mesothelioma
- Last Updated: September 30, 2020
- Status: Completed
- Location: Dallas, TX.
- 11C-Methionine PET/CT Imaging for Malignant Pleural Mesothelioma (MPM)
- Conditions: Mesothelioma
- Last Updated: September 29, 2020
- Status: Completed
- Safety and Efficacy of Listeria in Combination With Chemotherapy
- Conditions: Mesothelioma
- Last Updated: September 28, 2020
- Status: Completed
- Locations: San Francisco, CA. Tampa, FL. Chicago, IL. Bethesda, MD. Philadelphia, PA.
- Clinical Study of YS110 in Patients With Malignant Pleural Mesothelioma
- Conditions: Mesothelioma
- Last Updated: September 23, 2020
- Status: Completed
- Early Palliative Care in Advanced Lung and Gastrointestinal Malignancies
- Conditions: Lung Neoplasms, Small Cell Lung Carcinoma, Mesothelioma
- Last Updated: September 20, 2020
- Status: Completed
- Locations: Boston, MA.
- MesoTRAP: A Study Comparing Video-assisted Thoracoscopic Partial Pleurectomy/Decortication
- Conditions: Mesothelioma, Pleural Effusion
- Last Updated: September 15, 2020
- Status: Completed
- A Study Exploring the Safety and Efficacy of INCAGN01949 in Combination With Immune Therapies
- Conditions: Various Malignancies
- Last Updated: August 25, 2020
- Status: Completed
- Locations: Various cities in the United States.
- Radiofrequency Ablation for Refractory or Advanced Lung Cancer
- Conditions: Lung Neoplasms, Mesothelioma, Thymoma
- Last Updated: July 30, 2020
- Status: Completed
- Location: Los Angeles, CA.
- αDC1 Vaccine + Chemokine Modulatory Regimen (CKM) for Peritoneal Surface Malignancies
- Conditions: Neoplasms, Mesothelioma, Pancreatic Neoplasms, Gastric Carcinoma
- Last Updated: July 6, 2020
- Status: Completed
- Location: Pittsburgh, PA.
- Clinical and Histopathologic Characteristics of BAP1 Mutations
- Conditions: Melanoma, Carcinoma, Renal Cell, Mesothelioma, Cholangiocarcinoma, Uveal Neoplasms
- Last Updated: June 30, 2020
- Status: Completed
- Locations: Harrison, NY. New York, NY.
- A Study of CA-170 (Oral PD-L1, PD-L2 and VISTA Checkpoint Antagonist)
- Conditions: Lymphoma
- Last Updated: June 24, 2020
- Status: Completed
- Locations: San Francisco, CA. Denver, CO. Sarasota, FL. Chicago, IL. Detroit, MI. New York, NY. Huntersville, NC. Pittsburgh, PA. Nashville, TN. Houston, TX.
- Influence of Psychosocial Distress and Lifetime Trauma Exposure on Traumatic Stress
- Conditions: Mesothelioma
- Last Updated: May 22, 2020
- Status: Completed
- Location: Bethesda, MD.
- Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions
- Conditions: Mesothelioma, Malignant Pleural Effusion
- Last Updated: May 12, 2020
- Status: Completed
- Location: Philadelphia, PA.
- Phase II Study of PF-03446962 in Patients With Advanced Malignant Pleural Mesothelioma
- Conditions: Mesothelioma
- Last Updated: April 6, 2020
- Status: Completed
- Anti-TGF Monoclonal Antibody (GC1008) in Relapsed Malignant Pleural Mesothelioma
- Conditions: Mesothelioma
- Last Updated: March 31, 2020
- Status: Completed
- Location: Philadelphia, PA.
- Probe Based Confocal Laser Endomicroscopy for Pleural Malignancies Diagnosis
- Conditions: Carcinoma
- Last Updated: March 21, 2020
- Status: Completed
- Gene Therapy for Pleural Malignancies
- Conditions: Mesothelioma, Pleural Effusion
- Last Updated: March 16, 2020
- Status: Completed
- Location: Philadelphia, PA.
- Combination Gene Transfer and Chemotherapy
- Conditions: Mesothelioma
- Last Updated: March 13, 2020
- Status: Completed
- Location: Philadelphia, PA.
- Printed Education Materials in Patients Finishing Treatment for Various Cancers
- Conditions: Breast Neoplasms, Lung Neoplasms, Prostate Neoplasms, Colorectal Neoplasms, Mesothelioma, Thymoma
- Last Updated: February 27, 2020
- Status: Completed
- Locations: Philadelphia, PA.
- Everolimus for Inoperable Pleural Malignant Mesothelioma
- Conditions: Mesothelioma, Lung Neoplasms
- Last Updated: February 19, 2020
- Status: Completed
- Locations: Multiple locations across Arizona, California, Colorado, Connecticut, Georgia, Illinois, Indiana, Kansas, Michigan, Montana, New Mexico, North Carolina, Ohio, Oregon, Tennessee, Texas, Virginia, Washington, and Wyoming.
- Study of the Glutaminase Inhibitor CB-839 in Solid Tumors
- Conditions: Various Neoplasms
- Last Updated: February 13, 2020
- Status: Completed
- Locations: Multiple locations in California, Florida, Georgia, Maryland, Massachusetts, New York, Pennsylvania, Tennessee, and Texas.
- ATREUS – Phase II Study on Trabectedin in Malignant Pleural Mesothelioma (MPM)
- Conditions: Mesothelioma
- Last Updated: January 22, 2020
- Status: Completed
- Locations: Alessandria, Alabama, and Michigan.
- Ganetespib With Platinum for Malignant Pleural Mesothelioma
- Conditions: Mesothelioma
- Last Updated: November 8, 2019
- Status: Completed
- Phase Ib Study of Anetumab Ravtansine in Combination With Pemetrexed and Cisplatin
- Conditions: Mesothelioma
- Last Updated: November 6, 2019
- Status: Completed
- Locations: Illinois, Maryland, Michigan, and South Carolina.
- Eloxatin® Plus Gemcitabine Chemotherapy for Mesothelioma
- Conditions: Mesothelioma
- Last Updated: October 15, 2019
- Status: Completed
- Location: New York, NY.
- Early Diagnosis of Lung Cancer and Mesothelioma in Asbestos Workers
- Conditions: Lung Neoplasms, Mesothelioma
- Last Updated: October 3, 2019
- Status: Completed
- Phase I Study of Gene Induction Mediated by Sequential Decitabine/Depsipeptide Infusion
- Conditions: Lung Neoplasms, Small Cell Lung Carcinoma, Mesothelioma, Non-Small-Cell Lung Carcinoma
- Last Updated: September 27, 2019
- Status: Completed
- Location: Bethesda, MD.
- Single Dose FMT Infusion as an Adjunct to Keytruda for Metastatic Mesothelioma
- Conditions: Mesothelioma
- Last Updated: September 19, 2019
- Status: Completed
- Location: Ventura, CA.
- NGR015: Study in Second Line for Patients With Advanced Malignant Pleural Mesothelioma
- Conditions: Mesothelioma
- Last Updated: August 28, 2019
- Status: Completed
- Locations: California, Maryland, New York, Pennsylvania, and Texas.
- Re-directed T Cells for the Treatment of Malignant Pleural Mesothelioma
- Conditions: Mesothelioma, Pleural Effusion
- Last Updated: August 5, 2019
- Status: Completed
- LEE011 for Patients With CDK4/6 Pathway Activated Tumors (SIGNATURE)
- Conditions: Various Neoplasms
- Last Updated: July 16, 2019
- Status: Completed
- Locations: Multiple locations across the United States
- A Dose Escalation Study to Assess Safety of GSK2256098 (FAK Inhibitor) With Trametinib (MEK Inhibitor) in Patients With Advanced Solid Tumors
- Conditions:
- Last Updated: July 10, 2019
- Status: Completed
- Malignant Mesothelioma – Improving Quality of Life
- Conditions: Mesothelioma
- Last Updated: June 12, 2019
- Status: Completed
- SS1P and Pentostatin Plus Cyclophosphamide for Mesothelioma
- Conditions: Mesothelioma, Pancreatic Neoplasms, Lung Adenocarcinoma
- Last Updated: June 5, 2019
- Status: Completed
- Location: Bethesda, MD.
- E-MOSAIC Electronic Tool to Monitor Symptoms
- Last Updated: May 14, 2019
- Status: Completed
- Pemetrexed and Cisplatin Followed by Surgery With or Without Radiation Therapy
- Conditions: Mesothelioma
- Last Updated: May 13, 2019
- Status: Completed
- CART-meso in Mesothelin Expressing Cancers
- Conditions: Mesothelioma, Ovarian Carcinoma
- Last Updated: February 22, 2019
- Status: Completed
- Location: Philadelphia, PA.
- Chest Wall Motion Analysis in Disease
- Conditions: Various Chest Conditions
- Last Updated: February 21, 2019
- Status: Completed
- Study of NGR-hTNF Vs Placebo as Maintenance Treatment in Advanced Malignant Pleural Mesothelioma
- Conditions: Mesothelioma
- Last Updated: January 14, 2019
- Status: Completed
- Study of NGR-hTNF in Patients With Advanced Malignant Pleural Mesothelioma
- Conditions: Mesothelioma
- Last Updated: January 14, 2019
- Status: Completed
- Whey Protein Supplement With Exercise and Nutrition Program
- Conditions: Various Neoplasms
- Last Updated: January 10, 2019
- Status: Completed
- 18F-FSPG PET/CT for Cancer Patients on Therapy
- Conditions: Breast Neoplasms, Lung Neoplasms, Various Carcinomas
- Last Updated: December 11, 2018
- Status: Completed
- Locations: Stanford, CA.
- Phase I Study of Tremelimumab/ Tremelimumab+MEDI4736 in Japanese Solid Malignancies
- Conditions: Various Neoplasms, Lung Neoplasms
- Last Updated: December 11, 2018
- Status: Completed
- WT-1 Analog Peptide Vaccine in Malignant Pleural Mesothelioma After Combined Modality Therapy
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: November 1, 2018
- Status: Successfully Completed
- Location: New York, NY
- Safety and Efficacy of TTFields (150 kHz) Concomitant With Pemetrexed and Cisplatin or Carboplatin in Malignant Pleural Mesothelioma (STELLAR)
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: September 21, 2018
- Status: Successfully Completed
- Erlotinib Hydrochloride in Treating Patients With Malignant Peritoneal Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: September 17, 2018
- Status: Successfully Completed
- Location: Chicago, IL
- The ISET (Isolation by Size of Epithelial Tumor Cells) and the CellSearch Methods in Malignant Pleural Mesothelioma
- Conditions: Neoplasms, Mesothelioma, Malignant Mesothelioma, Parathyroid Neoplasms, Pleural Neoplasms, Thyroid Neoplasms, Pneumothorax, Thyroid Diseases
- Last Updated: July 20, 2018
- Status: Successfully Completed
- Bortezomib and Cisplatin as First-Line Therapy in Treating Patients With Malignant Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: July 11, 2018
- Status: Successfully Completed
- Quality of Life and Survivorship Care in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
- Conditions: Colonic Neoplasms, Germ Cell and Embryonal Neoplasms, Mesothelioma, Malignant Mesothelioma, Ovarian Epithelial Carcinoma, Germinoma, Ovarian Neoplasms, Lung Neoplasms, Pseudomyxoma Peritonei
- Last Updated: July 2, 2018
- Status: Successfully Completed
- Location: Winston-Salem, NC
- Intrapleural Photodynamic Therapy in a Multimodal Treatment for Patients With Malignant Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: June 12, 2018
- Status: Successfully Completed
- Phase I Dose Escalation Study of BAY94-9343 Given by Intravenous Infusion Every 3 Weeks in Japanese Subjects With Advanced Malignancies
- Conditions: Neoplasms
- Last Updated: June 1, 2018
- Status: Successfully Completed
- A Study in Non Small Cell Lung Cancer
- Conditions: Lung Neoplasms, Non-Small-Cell Lung Carcinoma
- Last Updated: May 16, 2018
- Status: Successfully Completed
- PXD101 as Second-Line Therapy in Treating Patients With Malignant Mesothelioma of the Chest That Cannot Be Removed By Surgery
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: May 4, 2018
- Status: Successfully Completed
- Location: Duarte, CA
- Phase II Study of IMC-A12 in Patients With Mesothelioma Who Have Been Previously Treated With Chemotherapy
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: March 13, 2018
- Status: Successfully Completed
- Location: Bethesda, MD
- Effect of FAS and FAS Ligand Polymorphisms on Patients With Platinum-Based-Treated Malignant Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: December 30, 2017
- Status: Successfully Completed
- S0509 – AZD2171 in Treating Patients With Malignant Pleural Mesothelioma That Cannot Be Removed By Surgery
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: December 27, 2017
- Status: Successfully Completed
- Locations: San Antonio, TX
- Sorafenib, Pemetrexed, and Cisplatin in Treating Patients With Advanced Solid Tumors
- Conditions: Mesothelioma
- Last Updated: November 27, 2017
- Status: Successfully Completed
- Locations: Minneapolis, MN
- Do Your Genes Put You at a Higher Risk of Developing Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: November 3, 2017
- Status: Successfully Completed
- Locations: Baltimore, MD; Rochester, MN; New York, NY; Winston-Salem, NC; Philadelphia, PA
- Autologous Redirected RNA Meso-CIR T Cells
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: September 16, 2017
- Status: Successfully Completed
- Location: Philadelphia, PA
- Nivolumab in Patients With Recurrent Malignant Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: September 13, 2017
- Status: Successfully Completed
- Radical Pleurectomy/Decortication (PD) and Intensity Modulated Radiotherapy (IMRT)
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: July 17, 2017
- Status: Successfully Completed
- Location: Houston, TX
- Feasibility of an Early Palliative Care Intervention for Metastatic Cancer Patients. A Phase 2 Study
- Conditions: Mesothelioma, Neoplasm Metastasis, Pancreatic Neoplasms
- Last Updated: July 6, 2017
- Status: Successfully Completed
- Intrapleural Administration of HSV1716 to Treat Patients With Malignant Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: June 8, 2017
- Status: Successfully Completed
- Pilot Study of Bisphosphonate Therapy (Zoledronic Acid) in Patients With Malignant Mesothelioma (UAB 0901)
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: April 24, 2017
- Status: Successfully Completed
- Locations: Birmingham, AL
- MesomiR 1: A Phase I Study of TargomiRs as 2nd or 3rd Line Treatment for Patients With Recurrent MPM and NSCLC
- Conditions: Lung Neoplasms, Non-Small-Cell Lung Carcinoma, Mesothelioma, Malignant Mesothelioma
- Last Updated: April 5, 2017
- Status: Successfully Completed
- Standard Chemotherapy With or Without Axitinib in Malignant Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: February 27, 2017
- Status: Successfully Completed
- A Study of Cetuximab Combined With Cisplatin or Carboplatin/Pemetrexed as First Line Treatment in Patients With Malignant Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: February 7, 2017
- Status: Successfully Completed
- Thrombin Generation and Platelet Activation in CRS/HIPEC
- Conditions: Mesothelioma, Peritoneal Neoplasms, Pseudomyxoma Peritonei, Carcinoma
- Last Updated: January 24, 2017
- Status: Successfully Completed
- Extrapleural Pneumonectomy/Pleurectomy Decortication, IHOC Cisplatin and Gemcitabine With Amifostine and Sodium Thiosulfate Cytoprotection for Resectable Malignant Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: January 19, 2017
- Status: Successfully Completed
- Location: Boston, MA
- Gemcitabine and Epirubicin in Treating Patients With Malignant Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: December 5, 2016
- Status: Successfully Completed
- Locations: Various cities across the United States
- Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases
- Conditions: Rare Diseases
- Last Updated: November 16, 2016
- Status: Successfully Completed
- Collecting Tumor Samples From Patients With Gynecological Tumors
- Conditions: Various Gynecological Tumors, Mesothelioma, Malignant Mesothelioma
- Last Updated: October 26, 2016
- Status: Successfully Completed
- Locations: Multiple locations across the United States
- A Single-Dose Pilot Study of Radiolabeled Amatuximab (MORAb-009) in Mesothelin Over Expressing Cancers
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: September 28, 2016
- Status: Successfully Completed
- Location: Bethesda, MD
- Avastin Plus Pemetrexed-Cisplatin Study for Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: September 1, 2016
- Status: Successfully Completed
- Genomic Analysis of Peritoneal Mesothelioma by CGH Arrays
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: July 25, 2016
- Status: Successfully Completed
- Capecitabine in Treating Patients With Malignant Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: July 12, 2016
- Status: Successfully Completed
- Locations: Multiple cities across the United States
- Dasatinib in Treating Patients With Previously Treated Malignant Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: July 11, 2016
- Status: Successfully Completed
- Locations: Multiple cities across the United States
- PTK787/ZK 222584 in Treating Patients With Unresectable Malignant Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: June 30, 2016
- Status: Successfully Completed
- Locations: Multiple cities across the United States
- Vascularity Impact on the Treatment Outcome in Malignant Pleural Mesothelioma (VITMPM)
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: May 29, 2016
- Status: Successfully Completed
- Tomotherapy Treatment Approach for Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: April 5, 2016
- Status: Successfully Completed
- Vaccine Therapy and GM-CSF for Acute Myeloid Leukemia, Myelodysplastic Syndromes, Non-Small Cell Lung Cancer, or Mesothelioma
- Conditions: Leukemia, Lung Neoplasms, Myelodysplastic Syndromes, Mesothelioma, Malignant Mesothelioma
- Last Updated: February 2, 2016
- Status: Successfully Completed
- Locations: New York, NY.
- B-Receptor Signaling in Cardiomyopathy Study
- Conditions: Various Cancer Types, Cardiomyopathies, Myelodysplastic Syndromes, Myeloproliferative Disorders, Amyloidosis
- Last Updated: November 16, 2015
- Status: Successfully Completed
- Locations: Stanford, CA.
- Cisplatin, Pemetrexed, and Imatinib Mesylate in Malignant Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: November 16, 2015
- Status: Successfully Completed
- Locations: Houston, TX.
- Efficacy Study of MORAb-009 (Amatuximab) in Subjects With Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: November 13, 2015
- Status: Successfully Completed
- Locations: Multiple cities across the United States
- Treatment of Peritoneal Cancer With Surgery, Perfused Heated Cisplatin, and Chemotherapy
- Conditions: Various Cancer Types, Peritoneal Neoplasms, Abdominal Neoplasms
- Last Updated: October 19, 2015
- Status: Successfully Completed
- Locations: Bethesda, MD.
- Intrapleural Gene Transfer for Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: September 21, 2015
- Status: Successfully Completed
- Locations: Philadelphia, PA.
- Oral PXD101 in Patients With Advanced Solid Tumors or Lymphoma
- Conditions: Various Solid Tumors, Lymphoma
- Last Updated: July 7, 2015
- Status: Successfully Completed
- Locations: New Haven, CT; New York, NY; Houston, TX.
- PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors
- Conditions: Various Solid Tumors
- Last Updated: July 7, 2015
- Status: Successfully Completed
- Locations: Scottsdale, AZ; Omaha, NE; Portsmouth, NH.
- Isolated Thoracic Perfusion (ITP-F) for MPM
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: June 9, 2015
- Status: Successfully Completed
- Immunotoxin Therapy for Advanced Cancer
- Conditions: Lung Neoplasms, Pancreatic Neoplasms, Head and Neck Neoplasms, Uterine Cervical Neoplasms, Mesothelioma, Malignant Mesothelioma
- Last Updated: April 29, 2015
- Status: Successfully Completed
- Locations: Bethesda, MD
- Immunotoxin Therapy for Advanced Solid Tumors
- Conditions: Lung Neoplasms, Pancreatic Neoplasms, Head and Neck Neoplasms, Uterine Cervical Neoplasms, Mesothelioma, Malignant Mesothelioma
- Last Updated: April 29, 2015
- Status: Successfully Completed
- Locations: Bethesda, MD; Winston-Salem, NC.
- Decitabine for Unresectable Lung or Esophageal Cancer or Malignant Mesothelioma of the Pleura
- Conditions: Lung Neoplasms, Esophageal Neoplasms, Mesothelioma, Malignant Mesothelioma
- Last Updated: April 28, 2015
- Status: Successfully Completed
- Locations: Bethesda, MD.
- Everolimus (RAD001) for the Treatment of Malignant Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: April 21, 2015
- Status: Successfully Completed
- Locations: Boston, MA; New York, NY; Philadelphia, PA.
- Phase II Study of Valproate and Doxorubicin in Malignant Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: February 11, 2015
- Status: Successfully Completed
- Pazopanib in Treating Patients With Malignant Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: January 28, 2015
- Status: Successfully Completed
- Locations: Rochester, MN.
- Bortezomib in Treating Patients With Malignant Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: December 30, 2014
- Status: Successfully Completed
- Molecular Predictors of Pemetrexed and Carboplatin Response in Malignant Pleural Mesothelioma (MPM) Patients
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: December 1, 2014
- Status: Successfully Completed
- Cediranib Maleate in Treating Patients With Malignant Mesothelioma That Cannot Be Removed By Surgery
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: July 25, 2014
- Status: Successfully Completed
- Locations: Chicago, IL.
- Analysis of the Response of Human Tumor Microvascular Endothelium to Ionizing Radiation
- Conditions: Various Cancer Types, Melanoma, Small Cell Lung Carcinoma, Colorectal Neoplasms, Ovarian Neoplasms, Liposarcoma
- Last Updated: July 23, 2014
- Status: Successfully Completed
- Locations: New York, NY.
- MORAb-009 Study for Pancreatic, Mesothelioma, and Ovarian/Lung Cancers
- Conditions: Lung Neoplasms, Non-Small-Cell Lung Carcinoma, Pancreatic Neoplasms, Ovarian Neoplasms, Mesothelioma, Malignant Mesothelioma
- Last Updated: July 16, 2014
- Status: Successfully Completed
- Locations: Baltimore, MD; Bethesda, MD; Philadelphia, PA.
- Sunitinib Treatment for Advanced Malignant Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: May 5, 2014
- Status: Successfully Completed
- Extrapleural Pneumonectomy With Heated Cisplatin for Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: March 26, 2014
- Status: Successfully Completed
- Locations: Boston, MA.
- Pleurectomy/Decortication and Heated Cisplatin for Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: March 26, 2014
- Status: Successfully Completed
- Locations: Boston, MA.
- Biomarkers for Early Detection of Asbestos/Vermiculite-Related Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: March 4, 2014
- Status: Successfully Completed
- Locations: Detroit, MI.
- Immunotherapy With Low-dose Cyclophosphamide for Malignant Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: February 26, 2014
- Status: Successfully Completed
- Combination Chemotherapy With or Without Bevacizumab for Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: February 10, 2014
- Status: Successfully Completed
- Locations: Chicago, IL.
- Rapamycin and Grapefruit Juice for Advanced Cancers
- Conditions: Metastatic Cancer
- Last Updated: January 16, 2014
- Status: Successfully Completed
- Locations: Chicago, IL.
- Fentanyl Sublingual Spray for Breakthrough Cancer Pain
- Conditions: Cancer Pain
- Last Updated: January 14, 2014
- Status: Successfully Completed
- Locations: Chandler, AZ.
- Serum Biomarkers for Mesothelioma Diagnosis
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: January 6, 2014
- Status: Successfully Completed
- Radiation Therapy to Prevent Metastatic Cancer in Mesothelioma Patients
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms, Postoperative Complications
- Last Updated: December 18, 2013
- Status: Successfully Completed
- Active Symptom Control for Malignant Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: August 6, 2013
- Status: Successfully Completed
- Combination Chemotherapy and Tamoxifen for Solid Tumors
- Conditions: Carcinoma, Sarcoma, Liver Neoplasms, Mesothelioma, Malignant Mesothelioma, Nervous System Neoplasms, Pheochromocytoma, Adrenocortical Carcinoma
- Last Updated: July 9, 2013
- Status: Successfully Completed
- Cyclophosphamide Plus Vaccine Therapy for Advanced Cancer
- Conditions: Breast Neoplasms, Lung Neoplasms, Pancreatic Neoplasms, Mesothelioma, Malignant Mesothelioma, Kidney Neoplasms
- Last Updated: July 9, 2013
- Status: Successfully Completed
- Locations: Los Angeles, CA.
- Video-Assisted Surgery vs. Talc Pleurodesis for Malignant Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: June 27, 2013
- Status: Successfully Completed
- Alanosine Treatment for Cancer
- Conditions: Lung Neoplasms, Pancreatic Neoplasms, Sarcoma, Mesothelioma, Malignant Mesothelioma
- Last Updated: June 25, 2013
- Status: Successfully Completed
- Locations: Birmingham, AL; Tucson, AZ; La Verne, CA; Los Angeles, CA; Boca Raton, FL; Chicago, IL; Skokie, IL; New York, NY; Nashville, TN; Houston, TX.
- Cisplatin With or Without Pemetrexed for Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: June 17, 2013
- Status: Successfully Completed
- Locations: New Brunswick, NJ; New York, NY; Cleveland, OH.
- Sorafenib Treatment for Malignant Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: June 4, 2013
- Status: Successfully Completed
- Locations: Chicago, IL; Boston, MA.
- SU5416 in Treating Patients With Malignant Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: May 31, 2013
- Status: Successfully Completed
- Locations: Chicago, IL; Decatur, IL; Evanston, IL; Park Ridge, IL; Peoria, IL; Springfield, IL; Fort Wayne, IN; South Bend, IN.
- Cisplatin, Interferon Alfa, Surgery, and Radiation Therapy for Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: April 16, 2013
- Status: Successfully Completed
- Locations: Marrero, LA; Philadelphia, PA; Newport News, VA.
- Survival After Cytoreductive Surgery and Hyperthermic Intra-peritoneal Chemotherapy for Peritoneal Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma, Hyperthermia, Fever
- Last Updated: March 15, 2013
- Status: Successfully Completed
- Erlotinib Treatment for Lung Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: January 23, 2013
- Status: Successfully Completed
- Locations: San Antonio, TX.
- Erlotinib for Solid Tumors with Liver or Kidney Dysfunction
- Conditions: Carcinoma, Breast Neoplasms, Lung Neoplasms, Prostatic Neoplasms, Pancreatic Neoplasms, Glioblastoma, Rectal Neoplasms, Head and Neck Neoplasms, Colonic Neoplasms, Urinary Bladder Neoplasms, Esophageal Neoplasms, Liver Neoplasms, Mesothelioma, Ovarian Epithelial Carcinoma, Laryngeal Neoplasms, Oropharyngeal Neoplasms, and more.
- Last Updated: January 15, 2013
- Status: Successfully Completed
- Locations: Chicago, IL.
- Gefitinib Treatment for Malignant Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: January 15, 2013
- Status: Successfully Completed
- Locations: Chicago, IL.
- Combination of Pemetrexed, Gemcitabine, or Carboplatin for Advanced Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: November 30, 2012
- Status: Successfully Completed
- Locations: Various locations across the US.
- Gemcitabine Plus Cisplatin for Unremovable Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: October 5, 2012
- Status: Successfully Completed
- Locations: Multiple locations across the US.
- Interleukin-12 Therapy for Abdominal Cancers
- Conditions: Colorectal Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Anus Neoplasms, Gallbladder Neoplasms
- Last Updated: July 27, 2012
- Status: Successfully Completed
- Locations: Houston, TX.
- Cisplatin With or Without Raltitrexed for Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: July 17, 2012
- Status: Successfully Completed
- Pemetrexed and Cisplatin Followed By Surgery and Radiation for Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: July 17, 2012
- Status: Successfully Completed
- Raltitrexed for Inoperable Malignant Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma, Lung Neoplasms
- Last Updated: July 17, 2012
- Status: Successfully Completed
- ZD1839 (IRESSA) for Malignant Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: June 5, 2012
- Status: Successfully Completed
- Combination Chemotherapy Prior to Surgery for Lung Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: May 14, 2012
- Status: Successfully Completed
- Inhaled Doxorubicin for Advanced Lung Tumors
- Conditions: Lung Neoplasms, Mesothelioma, Malignant Mesothelioma
- Last Updated: March 14, 2012
- Status: Successfully Completed
- Locations: Bethesda, MD.
- MS-275 for Advanced Solid Tumors or Lymphoma
- Conditions: Lymphoma
- Last Updated: March 14, 2012
- Status: Successfully Completed
- Locations: Bethesda, MD.
- Bevacizumab and Erlotinib for Previously Treated Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: December 23, 2011
- Status: Successfully Completed
- Locations: Chicago, IL; Boston, MA.
- Phase I Study of OSI-930 and Erlotinib in Various Cancers
- Conditions: Various Cancers
- Last Updated: September 26, 2011
- Status: Successfully Completed
- Locations: Tampa, FL.
- Bevacizumab, Pemetrexed, and Carboplatin as First-Line Therapy for Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: August 31, 2011
- Status: Successfully Completed
- Locations: Various locations across the US.
- Pemetrexed, Cisplatin, and Vitamin B12 for Unremovable Chest Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: May 14, 2011
- Status: Successfully Completed
- PV701 for Advanced or Recurrent Peritoneal Cancer
- Conditions: Peritoneal Cancer
- Last Updated: April 23, 2011
- Status: Successfully Completed
- Locations: New York, NY.
- SU011248 Dose Study in Advanced Solid Tumors
- Conditions: Advanced Solid Tumors
- Last Updated: April 7, 2011
- Status: Successfully Completed
- Locations: Aurora, CO.
- Liposomal-Cisplatin Analogue for Malignant Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: March 25, 2011
- Status: Successfully Completed
- Locations: New York, NY; Houston, TX.
- Vaccine Therapy for Non-small Cell Lung Cancer and Mesothelioma
- Conditions: Lung Neoplasms, Mesothelioma, Malignant Mesothelioma
- Last Updated: March 3, 2011
- Status: Successfully Completed
- Locations: Buffalo, NY.
- Surgery and Photodynamic Therapy for Malignant Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: February 25, 2011
- Status: Successfully Completed
- Locations: Buffalo, NY.
- Gemcitabine Long Infusion and Cisplatin for Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: November 17, 2010
- Status: Successfully Completed
- Dendritic Cell-based Immunotherapy for Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: November 15, 2010
- Status: Successfully Completed
- MKC1106-PP Immune Therapy for Advanced Cancer
- Conditions: Various Cancers
- Last Updated: August 2, 2010
- Status: Successfully Completed
- Locations: Tuscon, AZ; Tampa, FL; Sparks, NV; Lebanon, NH.
- Pemetrexed for Mesothelioma and Lung Cancer with Fluid Accumulation
- Conditions: Lung Neoplasms, Mesothelioma, Malignant Mesothelioma
- Last Updated: June 10, 2010
- Status: Successfully Completed
- Carboplatin and Vinorelbine for Malignant Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: September 17, 2009
- Status: Successfully Completed
- Phase II Trial of Neo-Adjuvant Pemetrexed Plus Cisplatin Followed by Surgery and Radiation for Pleural Mesothelioma
- Conditions: Mesothelioma, Pleural Neoplasms
- Last Updated: May 1, 2009
- Status: Successfully Completed
- Locations: Conducted at multiple prestigious centers, including San Francisco, Chicago, Baltimore, Boston, Detroit, New York, and Houston.
- Comparing Rigid Thoracoscopy to CT-Guided Pleural Needle Biopsy
- Conditions: Pleural Effusion, Pleural Diseases
- Last Updated: July 22, 2008
- Status: Successfully Completed
- Pemetrexed Plus Cisplatin in Malignant Pleural Mesothelioma Patients
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: November 5, 2007
- Status: Successfully Completed
- Safety Confirmation Study of Pemetrexed Plus Cisplatin for Malignant Pleural Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: April 10, 2007
- Status: Successfully Completed
- Pemetrexed Plus Best Supportive Care Versus Best Supportive Care Alone for Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: January 24, 2007
- Status: Successfully Completed
- Front-Line Chemotherapy: Pemetrexed Plus Gemcitabine for Malignant Pleural or Peritoneal Mesothelioma
- Conditions: Mesothelioma, Malignant Mesothelioma
- Last Updated: January 24, 2007
- Status: Successfully Completed
- Locations: Conducted in leading medical centers across the US, including Aurora, Tampa, Chicago, Boston, Detroit, Albuquerque, New York, Cleveland, Philadelphia, and Pittsburgh.