Research for New Mesothelioma Treatments

Research for New Mesothelioma Treatments | Therapies and Trials

Mesothelioma, a rare and formidable cancer, afflicts approximately 3,000 individuals in the United States each year. Its infrequency has left a void in our understanding, in stark contrast to more prevalent cancers like lung cancer. However, delving into the world of malignant mesothelioma research is paramount for several compelling reasons.

Early Detection

The potential to transform a patient’s prognosis lies in the early identification of mesothelioma. When the disease is caught in its nascent stages, a spectrum of treatment avenues opens up. These treatments can be more aggressive, often translating to improved mesothelioma survival rates when compared to cases diagnosed at later stages (stage 3 or stage 4).

Biomarkers

Recent strides in mesothelioma diagnostics have been marked by innovations in blood tests and biomarkers. Scientists are on a relentless quest to unveil biomarkers—distinctive substances within the bloodstream. These biomarkers may offer tantalizing hints of a mesothelioma diagnosis, manifest mesothelioma symptoms, or lay bare a history of asbestos exposure—the sole known catalyst for the disease.

One such trailblazing biomarker is HMGB1. In a recent breakthrough, HMGB1 was harnessed to:

  • Distinguish individuals who have been exposed to asbestos from those who haven’t.
  • Discern mesothelioma patients from individuals without asbestos exposure.
  • Separate mesothelioma patients from healthy individuals who bear the traces of asbestos exposure in their history.

While blood tests alone cannot authoritatively diagnose mesothelioma, they can serve as vital prompts for physicians to proceed with imaging scans and biopsies.

The Mesothelioma Breath Test

Emerging as a promising diagnostic tool is the mesothelioma breath test. A person exhales into a specialized device or container, and a sophisticated machine or tool scrutinizes their breath. This seemingly futuristic approach might hold the key to diagnosing mesothelioma.

One such technology, gas-chromatography-mass spectrometry (GC-MS), boasts an astonishing 97% accuracy in distinguishing mesothelioma patients from healthy individuals with a history of asbestos exposure.

To validate this revolutionary technology, rigorous research continues, with ongoing clinical trials diligently working towards its authentication.

Emerging Treatments and Clinical Trials

Malignant mesothelioma paints a challenging landscape, with patients typically grappling with survival times ranging from one to just over 5.5 years. Yet, there’s a beacon of hope emanating from the realm of mesothelioma treatment.

Before these innovative therapies can take their place as standard treatments, they undergo rigorous evaluation in clinical trials. While these trials entail specific eligibility criteria for participants, they often extend a lifeline to individuals who have exhausted conventional treatment options. If successful, clinical trials can ascend to the hallowed ground of FDA approval, becoming either a first- or second-line treatment.

The new-age treatments that have exhibited promise encompass gene therapy, immunotherapy, and photodynamic therapy. Among these, photodynamic therapy has garnered significant attention. When paired with surgery and chemotherapy, it has delivered survival periods as impressive as 7.3 years for pleural mesothelioma patients.

Evolution of Standard Treatments

The evolution of established treatments, including surgery, chemotherapy, and radiation, has been marked by significant strides. These advancements have not only enhanced the efficacy of these treatments but have also explored innovative combinations.

The Synergy of Chemotherapy and Immunotherapy

The National Comprehensive Cancer Network (NCCN) recently ushered in a transformative era by including a combination of Alimta®, cisplatin, and bevacizumab as a first-line treatment. This amalgamation fuses chemotherapy drugs with a targeted assault on tumor blood vessels. This option emerges as a ray of hope for patients ineligible for surgery. In a compelling study featuring 448 patients, those treated with the complete trio experienced an extended overall survival, stretching to 18.8 months. In contrast, the combination of Alimta® and cisplatin yielded a median survival of 16.1 months.

Immunotherapy, heralded by drugs like pembrolizumab and nivolumab/ipilimumab, has also showcased its prowess as a second-line alternative for patients whose mesothelioma progresses after front-line treatment. These drugs have ascended to become recommended therapies in the current NCCN guidelines.

Pioneering Radiation Therapies

Researchers have embarked on an exploration of how combined radiotherapy and surgery can yield superior outcomes in mesothelioma treatment. The SMART method (Surgery for Mesothelioma After Radiation Therapy) has emerged as a revolutionary treatment plan. It commences with radiation therapy and culminates in extrapleural pneumonectomy surgery. The impact of this strategy is underscored by a study revealing that it extended the typical lifespan of individuals diagnosed with epithelial mesothelioma patients to almost 43 months.

The quest for enhanced efficacy continues, with radiation therapy and immunotherapy preceding surgery gaining ground. Radiation therapy, in the form of IMRT, applied to pleural surfaces following lung-sparing pleurectomy, has also been explored, revealing both safety and promising effectiveness.

A Support System for Mesothelioma Patients

In the backdrop of these advancements, palliative care takes center stage, offering a lifeline to mesothelioma patients by alleviating their symptoms. As cancer cells metastasize, patients often grapple with intensified symptoms and the aftermath of grueling treatments. Palliative care steps in to mitigate these challenges, offering a higher quality of life. Recent case studies have dissected the efficacy of specific palliative treatments for both mesothelioma patients and survivors. These studies encompass the alleviating impacts of radiation therapy on individuals with pleural mesothelioma. Researchers continue to explore how radiation therapy can be harnessed palliatively, either as a standalone intervention or in synergy with other treatment modalities.

The Complexity of Mesothelioma

Within the mesothelioma spectrum, pleural mesothelioma reigns supreme, constituting a substantial majority of cases. It is followed by peritoneal mesothelioma. In contrast, pericardial and testicular mesothelioma each occupy a mere 1% or less of all mesothelioma cases. There exist even rarer cell types, which affect an exceedingly limited number of individuals. While research predominantly centers on malignant pleural mesothelioma, ongoing studies provide crucial insights into mesothelioma statistics, cancer progression, effective treatments, risk factors, and other invaluable facets that can revolutionize the diagnosis and treatment of this disease.

Cracking the Genetic Code of Mesothelioma

One intriguing avenue of research delves into the intersection of genetics and mesothelioma risk. Over the past decade, scientists have embarked on a quest to decipher how genetics can pinpoint individuals at heightened risk of developing mesothelioma and other asbestos-related cancers. During histological examinations, specialists can peer into patient DNA, unveiling chromosomal losses and gains that might provide critical insights into the diagnosis and prognosis of malignant mesothelioma. Although more research is needed to gauge their effectiveness, these genetic markers hold the potential to be invaluable aids in the battle against mesothelioma.

Of particular interest is the BAP1 gene, a tumor suppressor gene that has been linked to pancreatic cancer, ovarian cancer, breast cancer, and malignant mesothelioma. Studies have unveiled alterations in the BAP1 gene in numerous mesothelioma cases. One such study scrutinized both benign and malignant mesothelioma tumors, revealing functional BAP1 in all benign tumors. In stark contrast, 66% of mesothelioma tumors failed to express BAP1. While BAP1 has yet to secure its status as an official diagnostic test for mesothelioma, researchers advocate that the detection of BAP1 loss should trigger in-depth evaluation of a patient’s condition.

Mutated Genes in Mesothelioma

Several genes find themselves under scrutiny in the context of mesothelioma, including:

  1. BAP1 (BRCA1-associated protein 1): A tumor suppressor gene, BAP1 exhibits links to pancreatic cancer, ovarian cancer, breast cancer, and malignant mesothelioma.
  2. CDKN2A (Cyclin-dependent kinase inhibitor 2A) gene: Implicated in various cancers, this gene is also under investigation in mesothelioma.
  3. NF2 (Neurofibromin 2): Although primarily associated with neurofibromatosis, NF2 is now being explored in the context of mesothelioma.
  4. P53: The most frequently mutated gene in human cancers, P53 has been a subject of intense research in mesothelioma.

As researchers continue to probe the genetic underpinnings of mesothelioma, these discoveries may illuminate pathways to address genetic alterations. Moreover, they hold the promise of ushering in early detection methods, ultimately transforming the landscape of mesothelioma management.

The Unceasing Pursuit of Knowledge

The quest for knowledge regarding mesothelioma remains ceaseless, driven by the imperative need for data, tools for early detection, enhanced treatment options, and ultimately, a cure. This unrelenting pursuit not only equips physicians in their battle against the disease but also empowers patients and their families with a deeper comprehension of their journey—from diagnosis to treatment choices and prognosis.

Standing shoulder to shoulder with medical professionals, the mesothelioma community is a tapestry of survivors, patients, caregivers, specialists, researchers, and dedicated organizations and foundations. Together, they cast a beacon of hope, steadfast in their mission to raise awareness about this formidable disease and provide the financial support that fuels the engine of continuous research.