About David Schrump

Dr. David S. Schrump is a highly accomplished medical professional with a wealth of education and experience in his field. He graduated from the University of Connecticut School of Medicine and went on to complete his general surgery residency at the University of Chicago. Additionally, he completed a 3-year research fellowship in Human Cancer Immunology at Memorial Sloan-Kettering Cancer Center.

Following his thoracic surgery residency at the University of Michigan in 1993, Dr. Schrump joined the faculty at M.D. Anderson Cancer Center and later was appointed Head of Thoracic Oncology, Surgery Branch, NCI. He received NIH tenure in 2006. In 2009, he received an M.B.A. in Health Services Management from the Carey School of Business, Johns Hopkins University.

Dr. Schrump is a member of several professional organizations, including the American Association for Thoracic Surgery, Society of Thoracic Surgeons, John Alexander Society, International Association for the Study of Lung Cancer, Society of Clinical Oncologists, and the American Association for Cancer Research.

As Surgical Chief of the Branch, Dr. Schrump oversees clinical and translational research pertaining to thoracic malignancies, including the development of innovative molecular approaches to the diagnosis and treatment of these neoplasms. He has pioneered the development of epigenomic therapies for thoracic cancers. Using unique in vitro models and correlative experiments with surgical specimens, he has characterized epigenetic responses to tobacco carcinogens, and identified novel therapeutic targets in lung and esophageal cancers and pleural mesotheliomas.

His clinical protocols have demonstrated that chromatin remodeling agents simultaneously induce growth arrest and augment immunogenicity of thoracic malignancies; these efforts have provided rationale for combining epigenetic regimens with immunotherapies for these neoplasms.

Dr. Schrump's areas of expertise include Chromosome Biology, Lung Cancer, Thoracic Surgery, Cancer Epigenetics, MicroRNA, and Esophageal Cancer. He can be reached at the Center for Cancer Research, National Cancer Institute, Building 10, Room 4-3942, Bethesda, MD 20892. His contact number is 240-858-7000 and email address is david.schrump@nih.gov.